Epitopes recognized by human T lymphocytes in the ROP2 protein antigen of Toxoplasma gondii

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Epitopes recognized by human T lymphocytes in the ROP2 protein antigen of Toxoplasma gondii.

The ROP2 protein of Toxoplasma gondii possesses immunological and biological properties which have led to its proposal as a vaccine candidate. To identify epitopes recognized by human T cells in the ROP2 antigen, we submitted the sequence of this protein to three reported T-cell epitope prediction algorithms. Three sequences that were predicted by all three methods were selected (sequences 197 ...

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Evaluating the serological applications of Toxoplasma gondii rhoptry protein 1 (ROP1) antigen

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Detection of human Toxoplasma-specific immunoglobulins A, M, and G with a recombinant Toxoplasma gondii rop2 protein.

The Toxoplasma gondii rhoptry protein Rop2 was expressed in Escherichia coli as a fusion protein containing 44 kDa of the 55-kDa mature Rop2, supplied with six histidyl residues at the N-terminal end (Rop2196-561). Humoral response during Toxoplasma infection of humans was analyzed by immunoglobulin G (IgG), IgA, and IgM enzyme-linked immunosorbent assay with Rop2196-561 as the antigen substrat...

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ژورنال

عنوان ژورنال: Infection and Immunity

سال: 1996

ISSN: 0019-9567,1098-5522

DOI: 10.1128/iai.64.9.3858-3862.1996